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Publications of Team 1 (Demeneix)

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Is adult cardiac regeneration absent in Xenopus laevis yet present in Xenopus tropicalis ?
Marshall L, Girardot F, Demeneix BA, Coen L.
Cell Biosci. 2018 Apr 19 ;8:31.

Expression of the inactivating deiodinase, Deiodinase 3, in the pre-metamorphic tadpole retina.
Le Blay K, Préau L, Morvan-Dubois G, Demeneix B.
PLoS One. 2018 Apr 11 ;13(4):e0195374. doi : 10.1371/journal.pone.0195374. eCollection 2018.

Thyroid-disrupting chemicals and brain development : an update.
Mughal BB, Fini JB, Demeneix BA.
Endocr Connect. 2018 Apr ;7(4):R160-R186. doi : 10.1530/EC-18-0029. Epub 2018 Mar 23. Review.

Reference gene identification and validation for quantitative real-time PCR studies in developing Xenopus laevis.
Mughal BB, Leemans M, Spirhanzlova P, Demeneix B, Fini JB.
Sci Rep. 2018 Jan 11 ;8(1):496. doi : 10.1038/s41598-017-18684-1.


High-Fat Diet and Pregnancy : Are You Ready To Take Risks for Your Offspring ?
Clerget-Froidevaux MS, Sachs LM.
Endocrinology. 2017 Sep 1 ;158(9):2716-2718.

In Vivo Transfection of Naked DNA into Xenopus Tadpole Tail Muscle.
Marshall L, Girardot F, Demeneix BA, Coen L.
Cold Spring Harb Protoc. 2017 Nov 1 ;2017(11):pdb.prot099366. doi : 10.1101/pdb.prot099366.
Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism

Gothié JD, Sébillot A, Luongo C, Legendre M, Nguyen Van C, Le Blay K, Perret-Jeanneret M, Remaud S, Demeneix BA
Mol Metab 2017, 6:1551-1561

Endocrine disruptors : Flame retardants and increased risk of thyroid cancer.
Mughal BB, Demeneix BA.
Nat Rev Endocrinol. 2017 Nov ;13(11):627-628. doi : 10.1038/nrendo.2017.123. Epub 2017 Sep 22.

Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain.
Remaud S, Ortiz FC, Perret-Jeanneret M, Aigrot MS, Gothié JD, Fekete C, Kvárta-Papp Z, Gereben B, Langui D, Lubetzki C, Angulo MC, Zalc B, Demeneix B.
Elife. 2017 Sep 6 ;6. pii : e29996. doi : 10.7554/eLife.29996. [Epub ahead of print]

The Xenopus tadpole : An in vivo model to screen drugs favoring remyelination.
Mannioui A, Vauzanges Q, Fini JB, Henriet E, Sekizar S, Azoyan L, Thomas JL, Pasquier DD, Giovannangeli C, Demeneix B, Lubetzki C, Zalc B.
Mult Scler. 2017 Jul 1:1352458517721355. doi : 10.1177/1352458517721355.

Comparison of methods for calculating the health costs of endocrine disrupters : a case study on triclosan.
Prichystalova R, Fini JB, Trasande L, Bellanger M, Demeneix B, Maxim L.
Environ Health. 2017 Jun 9 ;16(1):55. doi : 10.1186/s12940-017-0265-x.

Using short-term bioassays to evaluate the endocrine disrupting capacity of the pesticides linuron and fenoxycarb.
Spirhanzlova P, De Groef B, Nicholson FE, Grommen SVH, Marras G, Sébillot A, Demeneix BA, Pallud-Mothré S, Lemkine GF, Tindall AJ, Du Pasquier D.
Comp Biochem Physiol C Toxicol Pharmacol. 2017 Jun 17. pii : S1532-0456(17)30123-0.

Functional characterisation of Xenopus thyroid hormone transporters mct8 and oatp1c1.
Mughal BB, Leemans M, L de Souza EC, le Mevel S, Spirhanzlova P, Visser T, Fini JB, Demeneix BA.
Endocrinology. 2017 Jun 7. doi : 10.1210/en.2017-00108.

Comparative approaches to understanding thyroid hormone regulation of neurogenesis.
Gothié JD, Demeneix B, Remaud S.
Mol Cell Endocrinol. 2017 May 22. doi : 10.1016/j.mce.2017.05.020

Agricultural expansion as risk to endangered wildlife : Pesticide exposure in wild chimpanzees and baboons displaying facial dysplasia.
Krief S, Berny P, Gumisiriza F, Gross R, Demeneix B, Fini JB, Chapman CA, Chapman LJ, Seguya A, Wasswa J.
Sci Total Environ. 2017 Nov 15 ;598:647-656. doi : 10.1016/j.scitotenv.2017.04.113

Persistent fibrosis, hypertrophy and sarcomere disorganisation after endoscopy-guided heart resection in adult Xenopus.
Marshall L, Vivien C, Girardot F, Péricard L, Demeneix BA, Coen L, Chai N.
PLoS One. 2017 Mar 9 ;12(3):e0173418. doi : 10.1371/journal.pone.0173418.

Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos.
Fini JB, Mughal BB, Le Mével S, Leemans M, Lettmann M, Spirhanzlova P, Affaticati P, Jenett A, Demeneix BA.
Sci Rep. 2017 Mar 7 ;7:43786. doi : 10.1038/srep43786.


Thyroglobulin Represents a Novel Molecular Architecture of Vertebrates.
Holzer G, Morishita Y, Fini JB, Lorin T, Gillet B, Hughes S, Tohmé M, Deléage G, Demeneix B, Arvan P, Laudet V.
J Biol Chem. 2016 Aug 5 ;291(32):16553-66.

Implication of thyroid hormone signaling in neural crest cells migration : Evidence from thyroid hormone receptor beta knockdown and NH3 antagonist studies.
Bronchain OJ, Chesneau A, Monsoro-Burq AH, Jolivet P, Paillard E, Scanlan TS, Demeneix BA, Sachs LM, Pollet N.
Mol Cell Endocrinol. 2016 Sep 10.

EU regulation of endocrine disruptors : a missed opportunity.
Kortenkamp A, Bourguignon JP, Slama R, Bergman Å, Demeneix B, Ivell R, Panzica G, Trasande L, Zoeller RT.
Lancet Diabetes Endocrinol. 2016 Aug ;4(8):649-50. doi : 10.1016/S2213-8587(16)30151-6. Epub 2016 Jul 1.

Science-based regulation of endocrine disrupting chemicals in Europe : which approach ?
Bourguignon JP, Slama R, Bergman Å, Demeneix B, Ivell R, Kortenkamp A, Panzica G, Trasande L, Zoeller RT.
Lancet Diabetes Endocrinol. 2016 Jun 13. pii : S2213-8587(16)30121-8. doi : 10.1016/S2213-8587(16)30121-8.

Thyroglobulin Represents a Novel Molecular Architecture of Vertebrates.
Holzer G, Morishita Y, Fini JB, Lorin T, Gillet B, Hughes S, Tohmé M, Deléage G, Demeneix B, Arvan P, Laudet V.
J Biol Chem. 2016 Jun 16. pii : jbc.M116.719047.

Scientific Issues Relevant to Setting Regulatory Criteria to Identify Endocrine Disrupting Substances in the European Union.
Slama R, Bourguignon JP, Demeneix B, Ivell R, Panzica G, Kortenkamp A, Zoeller T.
Environ Health Perspect. 2016 Apr 25.

Exposure to Thyroid-Disrupting Chemicals : A Transatlantic Call for Action.
Leung AM, Korevaar T, Peeters R, Zoeller RT, Koehrle J, Duntas LH, Brent GA, Demeneix BA.
Thyroid. 2016 Feb 23.


Differential thyroid hormone sensitivity of fast cycling progenitors in the neurogenic niches of tadpoles and juvenile frogs.
Préau L, Le Blay K, Saint Paul E, Morvan-Dubois G, Demeneix BA.
Mol Cell Endocrinol. 2015 Nov 25.

Oestrogen reporter transgenic medaka for non-invasive evaluation of aromatase activity.
Spirhanzlova P, Leleu M, Sébillot A, Lemkine GF, Iguchi T, Demeneix BA, Tindall AJ.
Comp Biochem Physiol C Toxicol Pharmacol. 2015 Sep 6. pii : S1532-0456(15)00115-5.

Xenopus tropicalis Genome Re-Scaffolding and Re-Annotation Reach the Resolution Required for In Vivo ChIA-PET Analysis.
Buisine N, Ruan X, Bilesimo P, Grimaldi A, Alfama G, Ariyaratne P, Mulawadi F, Chen J, Sung WK, Liu ET, Demeneix BA, Ruan Y, Sachs LM.
PLoS One. 2015 Sep 8 ;10(9):e0137526.

Neurobehavioral Deficits, Diseases and Associated Costs of Exposure to Endocrine Disrupting Chemicals in the European Union.
Bellanger M, Demeneix B, Grandjean P, Zoeller RT, Trasande L.
J Clin Endocrinol Metab. 2015 Mar 5:jc20144323. [Epub ahead of print]


Liver x receptor regulation of thyrotropin-releasing hormone transcription in mouse hypothalamus is dependent on thyroid status.
Ghaddab-Zroud R, Seugnet I, Steffensen KR, Demeneix BA, Clerget-Froidevaux MS.
PLoS One. 2014 Sep 17 ;9(9):e106983.

Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm.
Pourabdolhossein F, Mozafari S, Morvan-Dubois G, Mirnajafi-Zadeh J, Lopez-Juarez A, Pierre-Simons J, Demeneix BA, Javan M.
PLoS One. 2014 9:e106378

Rapid Fluorescent Detection of (Anti)androgens with spiggin-gfp Medaka.
Sébillot A, Damdimopoulou P, Ogino Y, Spirhanzlova P, Miyagawa S, Du Pasquier D, Mouatassim N, Iguchi T, Lemkine GF, Demeneix BA, Tindall AJ.
Environ Sci Technol. 2014 Aug 29.

Thyroid hormone signaling during early neurogenesis and its significance as a vulnerable window for endocrine disruption.
Biochim Biophys Acta. 2014 Jun 27. pii : S1874-9399(14)00167-9.
Préau L, Fini JB, Dubois GM, Demeneix B.

Thyroid Hormone Signaling and Adult Neurogenesis in Mammals.
Remaud S, Gothié JD, Morvan-Dubois G, Demeneix BA.
Front Endocrinol (Lausanne). 2014 Apr 28 ;5:62.

TR Alpha 2 Exerts Dominant Negative Effects on Hypothalamic Trh Transcription In Vivo.
Guissouma H, Ghaddab-Zroud R, Seugnet I, Decherf S, Demeneix B, Clerget-Froidevaux MS.
PLoS One. 2014 Apr 18 ;9(4):e95064.

On the origin and evolutionary history of NANOG.
Scerbo P, Markov GV, Vivien C, Kodjabachian L, Demeneix B, Coen L, Girardot F.
PLoS One. 2014 Jan 17 ;9(1):e85104. doi : 10.1371/journal.pone.0085104. eCollection 2014.


Pluripotency and induced nuclear reprogramming in vertebrates : new perspectives.
Scerbo P, Coen L.
Biol Aujourdhui. 2013 ;207(3):201-17.

Retinoic X receptor subtypes exert differential effects on the regulation of Trh transcription.
Decherf S, Seugnet I, Becker N, Demeneix BA, Clerget-Froidevaux MS.
Mol Cell Endocrinol. 2013 Dec 5 ;381(1-2):115-23. doi : 10.1016/j.mce.2013.07.016. Epub 2013 Jul 26.

In vivo endocrine disruption assessment of wastewater treatment plant effluents with small organisms.
Castillo L, Seriki K, Mateos S, Loire N, Guédon N, Lemkine GF, Demeneix BA, Tindall AJ.
Water Sci Technol. 2013 ;68(1):261-8. doi : 10.2166/wst.2013.179.

Thyroid hormone signaling and homeostasis during aging.
Bowers J, Terrien J, Clerget-Froidevaux MS, Gothié JD, Rozing MP, Westendorp RG, van Heemst D, Demeneix BA.
Endocr Rev. 2013 Aug ;34(4):556-89. doi : 10.1210/er.2012-1056. Epub 2013 May 21. Review.

Towards a humanized PPAR ? reporter system for in vivo screening of obesogens.
Punzon I, Latapie V, Le Mével S, Hagneau A, Jolivet P, Palmier K, Fini JB, Demeneix BA.
Mol Cell Endocrinol. 2013 Jul 15 ;374(1-2):1-9. doi : 10.1016/j.mce.2013.04.004. Epub 2013 Apr 16.

Relationship of thyroid function with obesity and type 2 diabetes in euthyroid Tunisian subjects.
Kouidhi S, Berhouma R, Ammar M, Rouissi K, Jarboui S, Clerget-Froidevaux MS, Seugnet I, Abid H, Bchir F, Demeneix B, Guissouma H, Elgaaied AB.
Endocr Res. 2013 ;38(1):15-23. doi : 10.3109/07435800.2012.699987. Epub 2012 Jun 29.

Inhibition of Sox2 Expression in the Adult Neural Stem Cell Niche In Vivo by Monocationic-based siRNA Delivery.
Remaud S, López-Juárez SA, Bolcato-Bellemin AL, Neuberg P, Stock F, Bonnet ME, Ghaddab R, Clerget-Froidevaux MS, Pierre-Simons J, Erbacher P, Demeneix BA, Morvan-Dubois G.
Mol Ther Nucleic Acids. 2013 Apr 23 ;2:e89. doi : 10.1038/mtna.2013.8.

Human subcutaneous adipose tissue Glut 4 mRNA expression in obesity and type 2 diabetes.
Kouidhi S, Berrhouma R, Rouissi K, Jarboui S, Clerget-Froidevaux MS, Seugnet I, Bchir F, Demeneix B, Guissouma H, Elgaaied AB.
Acta Diabetol. 2013 Apr ;50(2):227-32. doi : 10.1007/s00592-011-0295-8. Epub 2011 May 22.

Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians—screening for estrogen, androgen and thyroid hormone disruption.
Scholz S, Renner P, Belanger SE, Busquet F, Davi R, Demeneix BA, Denny JS, Léonard M, McMaster ME, Villeneuve DL, Embry MR.
Crit Rev Toxicol. 2013 Jan ;43(1):45-72. doi : 10.3109/10408444.2012.737762. Epub 2012 Nov 28. Review.


Thyroid hormone signalling favors neural stem cell commitment.
Remaud S, Morvan-Dubois G, Demeneix BA.
Med Sci (Paris). 2012 Dec ;28(12):1050-2. doi : 10.1051/medsci/20122812010. Epub 2012 Dec 21. French. No abstract available.

Live imaging of targeted cell ablation in Xenopus : a new model to study demyelination and repair.
Kaya F, Mannioui A, Chesneau A, Sekizar S, Maillard E, Ballagny C, Houel-Renault L, Dupasquier D, Bronchain O, Holtzmann I, Desmazieres A, Thomas JL, Demeneix BA, Brophy PJ, Zalc B, Mazabraud A.
J Neurosci. 2012 Sep 12 ;32(37):12885-95.

Ventx factors function as Nanog-like guardians of developmental potential in Xenopus.
Scerbo P, Girardot F, Vivien C, Markov GV, Luxardi G, Demeneix B, Kodjabachian L, Coen L.
PLoS One. 2012 ;7(5):e36855. doi : 10.1371/journal.pone.0036855. Epub 2012 May 14.

Thyroid hormone signaling acts as a neurogenic switch by repressing Sox2 in the adult neural stem cell niche.
López-Juárez A, Remaud S, Hassani Z, Jolivet P, Pierre Simons J, Sontag T, Yoshikawa K, Price J, Morvan-Dubois G, Demeneix BA.
Cell Stem Cell. 2012 May 4 ;10(5):531-43. doi : 10.1016/j.stem.2012.04.008.

Non-viral expression of mouse Oct4, Sox2, and Klf4 transcription factors efficiently reprograms tadpole muscle fibers in vivo.
Vivien C, Scerbo P, Girardot F, Le Blay K, Demeneix BA, Coen L.
J Biol Chem. 2012 Mar 2 ;287(10):7427-35. doi : 10.1074/jbc.M111.324368. Epub 2012 Jan 9. Erratum in : J Biol Chem. 2012 Jun 22 ;287(26):22151.

Parallel biotransformation of tetrabromobisphenol A in Xenopus laevis and mammals : Xenopus as a model for endocrine perturbation studies.
Fini JB, Riu A, Debrauwer L, Hillenweck A, Le Mével S, Chevolleau S, Boulahtouf A, Palmier K, Balaguer P, Cravedi JP, Demeneix BA, Zalko D.
Toxicol Sci. 2012 Feb ;125(2):359-67. doi : 10.1093/toxsci/kfr312. Epub 2011 Nov 15.


The obesogen hypothesis : a shift of focus from the periphery to the hypothalamus.
Decherf S, Demeneix BA.
J Toxicol Environ Health B Crit Rev. 2011 ;14(5-7):423-48. doi : 10.1080/10937404.2011.578561. Review.

Generation of fluorescent zebrafish to study endocrine disruption and potential crosstalk between thyroid hormone and corticosteroids.
Terrien X, Fini JB, Demeneix BA, Schramm KW, Prunet P.
Aquat Toxicol. 2011 Sep ;105(1-2):13-20. doi : 10.1016/j.aquatox.2011.04.007. Epub 2011 May 27.

Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responses.
Bilesimo P, Jolivet P, Alfama G, Buisine N, Le Mevel S, Havis E, Demeneix BA, Sachs LM.
Mol Endocrinol. 2011 Feb ;25(2):225-37. doi : 10.1210/me.2010-0269. Epub 2011 Jan 14.

Adiponectin expression and metabolic markers in obesity and Type 2 diabetes.
Kouidhi S, Jarboui S, Marrakchi R, Froidevaux MS, Seugnet I, Abid H, Bchir F, Brahem M, Demeneix B, Guissouma H, Elgaaied AB.
J Endocrinol Invest. 2011 Feb ;34(2):e16-23. doi : 10.3275/7204. Epub 2010 Jul 22.

Bisphenol A induces otolith malformations during vertebrate embryogenesis.
Gibert Y, Sassi-Messai S, Fini JB, Bernard L, Zalko D, Cravedi JP, Balaguer P, Andersson-Lendahl M, Demeneix B, Laudet V.
BMC Dev Biol. 2011 Jan 26 ;11:4. doi : 10.1186/1471-213X-11-4.


Relationship between subcutaneous adipose tissue expression of leptin and obesity in Tunisian patients.
Kouidhi S, Jarboui S, Clerget Froidevaux MS, Abid H, Demeneix B, Zaouche A, Benammar Elgaaied A, Guissouma H.
Tunis Med. 2010 Aug ;88(8):569-72.

Disruption of thyroid hormone-dependent hypothalamic set-points by environmental contaminants.
Decherf S, Seugnet I, Fini JB, Clerget-Froidevaux MS, Demeneix BA.
Mol Cell Endocrinol. 2010 Jul 29 ;323(2):172-82. doi : 10.1016/j.mce.2010.04.010. Epub 2010 Apr 24.

Peroxisome proliferator-activated receptor-gamma (PPARgamma) modulates hypothalamic Trh regulation in vivo.
Kouidhi S, Seugnet I, Decherf S, Guissouma H, Elgaaied AB, Demeneix B, Clerget-Froidevaux MS.
Mol Cell Endocrinol. 2010 Apr 12 ;317(1-2):44-52. doi : 10.1016/j.mce.2009.11.001. Epub 2009 Nov 10.

Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression.
Decherf S, Seugnet I, Kouidhi S, Lopez-Juarez A, Clerget-Froidevaux MS, Demeneix BA.
Proc Natl Acad Sci U S A. 2010 Mar 2 ;107(9):4471-6. doi : 10.1073/pnas.0905190107. Epub 2010 Feb 16.