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Offre de thèse

by Administrateur - published on , updated on

Un financement de Thèse est disponible dans l’équipe du Pr Tostivint.
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A 3-year funded PhD position is available at the Muséum National d’Histoire Naturelle in Paris to study the mechanisms of DNA repair in vivo during zebrafish development.
In living organisms, DNA is continuously exposed to damage. Among the varieties of DNA damage, double strand breaks (DSBs) are one of the most severe threats to genome integrity. Eukaryotes have multiple evolutionary conserved pathways to repair DSBs, including homologous recombination, non-homologous end-joining (NHEJ) and the lesser-known microhomology mediated end-joining (MMEJ) pathway. MMEJ was first considered as a backup for NHEJ but is now recognized as an independent pathway, involving specific proteins
such as DNA polymerase θ, and it has been found to be prevalent for repair of DSBs induced by CRISPR-Cas9 in early zebrafish embryos as well as in several other experimental models.
The aim of the PhD project is to understand the importance and regulation of DNA repair pathways during zebrafish embryonic development. We will use molecular, transgenic and imaging approaches to analyse how various cell types deal with DNA double strand breaks, in particular by MMEJ.
We are seeking a highly motivated and enthusiastic candidate with a Masters degree in either developmental biology or molecular biology.

Interested applicants should send a detailed resume and two letters of recommendation to: Jean-Paul Concordet (jean-paul.concordet@mnhn.fr) and Guillaume Pézeron (guillaume.pezeron@mnhn.fr).

The project will be carried out in the context of a collaboration between their two respective labs at the Muséum National d’Histoire Naturelle and the team of Dr T. Momose, CNRS, Villefranche-sur-mer.